Human Leukemia Cell
نویسندگان
چکیده
We report that erythroid-potentiating activity (EPA). known to stimulate the proliferation of normal human erythroid precursors in vitro. has a growth-promoting effect on human K562 erythroleukemia cells and Friend mouse erythroleukemia cells. Detailed studies were carried out using an EPA produced by a human T-lymphoblast line (Mo). Although EPA has not been purified to homogeneity. several observations indicate that the factor elaborated by Mo cells that stimulates erythroleukemia cell growth is the EPA molecule. The erythroleukemia growth factor cofractionates with EPA using gel exclusion chromatography. isoelectric focusing. and ion exchange chromatography. In addition. the activities exhibit similar
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